A urine dipstick and microscopy together pack a remarkable amount of clinical information into a few squares of colour and a slide. This interpreter takes those results and surfaces the classic patterns and differentials they point to, including the combinations that change the meaning of an individual finding.
What each dipstick field detects
Understanding what the chemistry behind each pad is measuring helps interpret unexpected results:
| Dipstick field | What it detects | Common false results |
|---|---|---|
| Leucocyte esterase | Enzyme from white blood cells | False positive: vaginal contamination |
| Nitrites | Reduction of dietary nitrate by certain bacteria | False negative: non-nitrite-forming organisms (Enterococcus, Staph saprophyticus) |
| Blood | Haem group (RBCs, haemoglobin, myoglobin) | False positive: myoglobinuria after muscle injury |
| Protein | Mainly albumin | False negative: Bence-Jones (light chain) protein |
| Glucose | Glucose oxidase reaction | False negative: Vitamin C in high dose |
| Ketones | Acetoacetate (not beta-hydroxybutyrate) | False negative: BOHB-predominant ketosis |
| pH | Acid-base of urine | Affected by standing (alkalinises) and diet |
| Specific gravity | Solute concentration | Falsely elevated: IV contrast agents |
How it works
The tool applies the standard rule logic clinicians use at the bedside. Each parameter has well-established associations, and several only become meaningful in combination:
leucocytes + nitrites -> likely bacterial UTI
blood + dysmorphic RBCs -> glomerular source
blood + isomorphic RBCs -> lower-tract / urological source
protein + RBC casts -> nephritic picture
glucose + ketones -> uncontrolled diabetes / DKA concern
WBC casts -> pyelonephritis / interstitial nephritis
alkaline pH + pyuria -> consider urea-splitting Proteus / struvite
Microscopy fields, when entered, refine the dipstick. Red cell morphology and cast type are what separate a kidney problem from a bladder one, so the output shifts accordingly.
Reading casts: the most specific microscopy finding
Casts form in renal tubules when protein or cells are trapped in a cylindrical mould made from Tamm-Horsfall mucoprotein. Because they can only form in the kidney, any cast — even a plain hyaline cast — localises pathology to the renal parenchyma:
- Hyaline casts — normal in small numbers, or concentrated urine; no specific pathology.
- Granular / “muddy brown” casts — classically acute tubular necrosis (ATN).
- Red cell casts — glomerulonephritis until proven otherwise.
- White cell casts — pyelonephritis or acute interstitial nephritis.
- Waxy / broad casts — chronic kidney disease with tubular atrophy.
No casts in a urine sample with heavy proteinuria and microscopic haematuria still warrants glomerulonephritis workup — casts can be missed if the sample is not centrifuged promptly or the microscopy is superficial.
Tips and clinical context
A positive blood dipstick is not always red cells: haemoglobin and myoglobin trigger it too, which is why microscopy confirmation matters. Trace proteinuria is frequently benign and transient after fever or exercise, while persistent or heavy proteinuria warrants quantification with a protein-to-creatinine ratio. Bacteria seen without leucocytes often signal contamination or asymptomatic bacteriuria rather than infection needing treatment.
This tool is a teaching aid that flags classic patterns; it does not diagnose. Infection should always be confirmed by culture in the appropriate clinical context before antibiotics are prescribed.