Controlled substances are ranked by two very different systems on either side of the Atlantic. This reference lets you search a drug and see its US DEA schedule and its UK Misuse of Drugs class together, so you can compare how each regulator treats the same substance.
The US DEA schedule explained
The DEA schedule runs from I to V and answers two questions simultaneously: how high is the abuse potential, and does the drug have an accepted medical use in the United States?
| DEA Schedule | Abuse potential | Medical use | Examples |
|---|---|---|---|
| I | High | None (federally) | Heroin, LSD, cannabis (federal), psilocybin |
| II | High | Accepted | Oxycodone, fentanyl, methamphetamine, cocaine (topical) |
| III | Moderate | Accepted | Ketamine, anabolic steroids, buprenorphine |
| IV | Low | Accepted | Benzodiazepines (alprazolam, diazepam), zolpidem |
| V | Lowest | Accepted | Some cough preparations with codeine |
Schedule II drugs require a written prescription with no refills in most states. The controls tighten, not loosen, as the schedule number decreases — Schedule II is more restricted than Schedule IV.
The UK class system explained
The UK Misuse of Drugs Act classes rank harm to set criminal penalties for possession and supply. Unlike the DEA schedule, the class does not directly encode whether the substance has medical use — that is handled by a separate UK Schedule system governing prescribing and storage.
| UK Class | Harm ranking | Penalties (supply) | Examples |
|---|---|---|---|
| A | Highest | Up to life imprisonment | Heroin, cocaine, ecstasy, LSD, psilocybin |
| B | Intermediate | Up to 14 years | Cannabis, amphetamines, codeine, ketamine |
| C | Lower | Up to 14 years | Benzodiazepines, GHB, anabolic steroids |
Why the systems diverge
The most striking example is cannabis: Schedule I in the US (no accepted federal medical use, high abuse potential) but Class B in the UK (intermediate harm, lower criminal tier than heroin). The systems measure different things — one measures medical utility and abuse potential, the other measures relative harm to set criminal sentences — so disagreements are expected rather than inconsistencies.
Another example: ketamine is Schedule III (US) but Class B (UK), reflecting how each country’s regulators weigh its anesthetic medical use against its abuse risk. Codeine shifts US schedules depending on concentration and combination product — it can be Schedule II, III, or V — showing how formulation affects classification.
Important limitations
Classifications change when new evidence emerges, when rescheduling petitions succeed, or when laws are updated. US state law frequently diverges from federal DEA scheduling for cannabis and psychedelics. Penalties also depend on quantity, intent (possession vs supply), prior history, and jurisdiction. Use this as an educational reference only — not as legal or medical advice.